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ISM1 anticorps (PE)

ISM1 Reactivité: Souris FACS Hôte: Rat Monoclonal B054B6 PE
N° du produit ABIN2662774
  • Antigène Voir toutes ISM1 Anticorps
    ISM1 (Isthmin 1 (ISM1))
    Reactivité
    • 24
    • 18
    Souris
    Hôte
    • 24
    • 1
    Rat
    Clonalité
    • 24
    • 1
    Monoclonal
    Conjugué
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ISM1 est conjugé à/à la PE
    Application
    • 16
    • 14
    • 13
    • 3
    • 1
    Flow Cytometry (FACS)
    Purification
    The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
    Clone
    B054B6
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product ISM1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.2 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Protect from prolonged exposure to light. Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Antigène
    ISM1 (Isthmin 1 (ISM1))
    Autre désignation
    Isthmin-1 (ISM1 Produits)
    Synonymes
    anticorps 5430433G21Rik, anticorps Ism, anticorps C20orf82, anticorps ISM, anticorps Isthmin, anticorps bA149I18.1, anticorps dJ1077I2.1, anticorps ism, anticorps xIsm, anticorps isthmin 1, anticorps isthmin 1, angiogenesis inhibitor, anticorps isthmin 1, angiogenesis inhibitor L homeolog, anticorps ism1, anticorps Ism1, anticorps ISM1, anticorps ism1.L
    Sujet
    Isthmin is a secreted protein, and it was initially identified in the Xenopus midbrain-hindbrain organizer (MHB) or isthmus organizer, where it is highly expressed. The MHB is an important signaling center in vertebrates and regulates the polarized morphological differentiation of the adjacent tectum and cerebellum. Mouse Isthmin is a 454 amino acid protein containing a Thrombospondin Type 1 Repeat (TSR) domain in the central region and an Adhesion-associated domain in MUC4 and Other Proteins (AMOP) domain at the C-terminal. The TSR domains are highly conserved with 98 % identity between mouse and human, 87-88 % identity between mouse and Xenopus. The C-terminal AMOP domains are also highly conserved with 99 % identity between mouse and human, 91 % identity between mouse and Xenopus. Mouse isthmin nucleotide sequence is similar to the human chromosome 20 open reading frame 82 (C20orf82). The Ism1 gene is conserved in human, chimpanzee, dog, cow, chicken, and zebrafish. Isthmin has angiostatic activity in vitro and in vivo. Isthmin inhibits EC capillary network formation mainly by interfering with the early stages of in vitro angiogenesis on matrigel. Isthmin inhibits VEGF-induced EC proliferation and induces apoptosis in the presence of VEGF. Overexpression of isthmin in B16 melanoma inhibits tumor growth and tumor angiogenesis in mice. Knockdown of isthmin in zebrafish embryos leads to abnormal intersegmental vessel (ISV) formation in the trunk.
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