OPRD1 anticorps (PE)

N° du produit ABIN2663677

Détail du produit anti-OPRD1 anticorps (PE)

Antigène: OPRD1 (Opioid Receptor, delta 1 (OPRD1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp OPRD1 est conjugé à/à la PE

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: DOR7D2A4

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur OPRD1

Antigène: OPRD1 (Opioid Receptor, delta 1 (OPRD1))

Autre désignation: delta Opioid Receptor (OPRD1 Produits)

Synonymes: anticorps OPRD, anticorps DOR-1, anticorps Nbor, anticorps mDOR, anticorps opioid receptor delta 1, anticorps opioid receptor, delta 1, anticorps OPRD1, anticorps Oprd1

Sujet: Opioid receptors are the members of seven transmembrane G-protein coupled receptors. At least 3 types of opioid receptors, μ, κ, and δ, have been identified. Human δ-opioid receptor, know as OPRD, DOR, or hDOR, is primarily expressed in brain, especially in the areas of cortex, including olfactory bulb, hippocampus, and amygdale, as well as in basal ganglia and hypothalamus. Human OPRD gene has been mapped at chromosome 1p34.3-p36.1. The endogenous ligands for the OPRD are enkephalins. The third extracellular loop of the OPRD is critical for ligand binding. The ligands binding and signal transduction functions of δ-receptor can be synergized by forming heterodimers with κ-receptor. Activation of opioid receptor inhibits cAMP production, increases phosphodiesterase activity, and results in analgesia and convulsions. Recent studies have indicated that OPRD is involved in the mechanism of heroin dependence.

Pathways: Protein targeting to Nucleus