IFN-gamma R beta Chain anticorps (PE)

N° du produit ABIN2663758

Cet anticorps Hamster Monoclonal détecte spécifiquement dans ELISA (Detection), IP et Neut. Il présente une réactivité envers Souris.

Aperçu rapide pour IFN-gamma R beta Chain anticorps (PE) (ABIN2663758)

Antigène: IFN-gamma R beta Chain

Reactivité: Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: PE

Application: ELISA (Detection), Immunoprecipitation (IP), Neutralization (Neut)

Clone: MOB-47

Détail du produit

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détail du antigène

Antigène: IFN-gamma R beta Chain

Sujet: IFN-γ receptor β chain is also known as IFN-γ AF-1. This 60-65 kD class II cytokine receptor pairs with CDw119 to form the IFN-γ receptor. CDw119 serves as the IFN-γ-binding chain and associates with the IFN-γ β chain which is required for receptor signaling. The extracellular portion of both the IFN-γ receptor α and β chains must be species matched. The IFN-γ receptor β chain is expressed at low levels on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses.