CCL28 anticorps (Biotin)

N° du produit ABIN2664097

Détail du produit anti-CCL28 anticorps (Biotin)

Antigène: CCL28 (Chemokine (C-C Motif) Ligand 28 (CCL28))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCL28 est conjugé à/à la Biotin

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: J139G11

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CCL28

Antigène: CCL28 (Chemokine (C-C Motif) Ligand 28 (CCL28))

Autre désignation: CCL28 (CCL28 Produits)

Synonymes: anticorps Scya28, anticorps CCL28, anticorps ccl28, anticorps nrpb, anticorps enc-1, anticorps pig10, anticorps Encr-3, anticorps klhl35, anticorps Xencr-3, anticorps tp53i10, anticorps LOC100303767, anticorps CCK1, anticorps MEC, anticorps SCYA28, anticorps C-C motif chemokine ligand 28, anticorps ectodermal-neural cortex 1 (with BTB domain), anticorps C-C motif chemokine 28, anticorps chemokine (C-C motif) ligand 28, anticorps Ccl28, anticorps CCL28, anticorps ccl28, anticorps enc1, anticorps LOC100303767

Sujet: Human CCL28 was identified in an EST database using a human chemokine consensus sequence. CCL28 is constitutively expressed by mucosal epithelial cells such as exocrine glands, trachea, and colon. Acinar epithelial cells in human and mouse salivary glands are strongly positive for CCL28 by immunostaining, and human saliva and milk contain high concentrations of CCL28. Furthermore, it is known that human and mouse CCL28 have antimicrobial activity attributed to the C-terminus of CCL28 against Candida albicans, Gram-negative bacteria, and Gram-positive bacteria. In addition, using a CCR10 deficient mouse model, it was shown that CCR10 plays a critical role in localization and accumulation of IgA ASC in lactating mammary glands. Also, it has been described that CCL28 is upregulated in epithelial inflammation, and this upregulation allows the recruitment of Tregs expressing CCR10. In fact, a subpopulation of CCR10-expressing CD25+CD4+FOXP3+ Tregs with potent anti-inflammatory properties was isolated from a chronically inflamed human liver. Information suggests that tumor hypoxia promotes the recruitment of Tregs through induction of expression of CCL28, and this induction is mediated by the hypoxia inducible factor-1α (HIF-1α). Therefore, tumor hypoxia promotes tolerance and angiogenesis via CCL28 and Tregs.