CCRL1 anticorps

N° du produit ABIN2664103

Détail du produit anti-CCRL1 anticorps

Antigène: CCRL1 (Chemokine (C-C Motif) Receptor-Like 1 (CCRL1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCRL1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Intracellular Flow Cytometry (ICFC)

Purification: The antibody was purified by affinity chromatography.

Clone: 13E11

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CCRL1

Antigène: CCRL1 (Chemokine (C-C Motif) Receptor-Like 1 (CCRL1))

Autre désignation: CCX-CKR (CCRL1 Produits)

Synonymes: anticorps CC-CKR-11, anticorps CCBP2, anticorps CCR-11, anticorps CCR10, anticorps CCR11, anticorps CCRL1, anticorps CCX CKR, anticorps CCX-CKR, anticorps CKR-11, anticorps PPR1, anticorps VSHK1, anticorps A630091E18Rik, anticorps CCX-CKR1, anticorps Ccrl1, anticorps Cmkbrl1, anticorps atypical chemokine receptor 4, anticorps chemokine (C-C motif) receptor-like 1, anticorps Chemokine receptor-like 1, anticorps chemerin chemokine-like receptor 1, anticorps ACKR4, anticorps Ackr4, anticorps CCRL1, anticorps cml1, anticorps CMKLR1

Sujet: Human CCX-CKR, also known as CCRL1, is a 40 kD, G-protein-coupled, seven transmembrane receptor. CCRL1 is a decoy receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25 that regulates chemotaxis of lymphocytes and cancer cells. Chemokine binding by CCX-CKR causes its internalization, reducing levels of available chemokine, and thus regulating migration of lymphocytes and cancerous cells. CCX-CKR is expressed by stromal cells of skin-draining lymph nodes, thymic epithelial cells, and immature dendritic cells (DCs). A low CCX-CKR expression in tumor cells correlates with a poor survival rate of breast cancer patients.