CCR4 anticorps

N° du produit ABIN2664334

Détail du produit anti-CCR4 anticorps

Antigène: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Reactivité: Souris

Hôte: Hamster arménien

Clonalité: Monoclonal

Conjugué: Cet anticorp CCR4 est non-conjugé

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 2G12

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CCR4

Antigène: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Autre désignation: CD194 (CCR4 Produits)

Synonymes: anticorps CC-CKR-4, anticorps CD194, anticorps CKR4, anticorps CMKBR4, anticorps ChemR13, anticorps HGCN:14099, anticorps K5-5, anticorps Ccr4, anticorps C-C CKR-4, anticorps CHEMR1, anticorps Cmkbr4, anticorps LESTR, anticorps Sdf1r, anticorps C-C motif chemokine receptor 4, anticorps chemokine (C-C motif) receptor 4, anticorps CCR4, anticorps Ccr4

Sujet: Mouse CCR4 cDNA contains 1531 bp, and encodes a protein of 360 amino acids that is 85 % identical to human CCR4. CCR4 binds CCL17 (TARG) and CCL22 (MDC). Naive T cells, bearing receptors for cutaneous antigens, become activated in skin-draining lymph nodes and express cutaneous lymphocyte antigen (CLA), which confers to these cells the capacity to migrate into the skin to exert their normal effector functions (1). CCR4 and CCR10 play an important role in the ligand-mediated recruitment of T cells into the skin in mice and humans, specifically with regards to tethering, firm adhesion, and subsequent extravasation to the site of injury (2,3). CCR4 is expressed in cutaneous regulatory T cells (Tregs). These cells are crucial for the induction and maintenance of self-tolerance and are present in peripheral tissues such as skin and gut under normal, noninflamed conditions (4).In addition, recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor and its ligand CCL22 (5).