CCR4 anticorps

N° du produit ABIN2664335

Détail du produit anti-CCR4 anticorps

Antigène: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCR4 est non-conjugé

Application: Intracellular Flow Cytometry (ICFC)

Réactivité croisée: Cynomolgus

Purification: The antibody was purified by affinity chromatography.

Clone: L291H4

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CCR4

Antigène: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Autre désignation: CD194 (CCR4 Produits)

Synonymes: anticorps CC-CKR-4, anticorps CD194, anticorps CKR4, anticorps CMKBR4, anticorps ChemR13, anticorps HGCN:14099, anticorps K5-5, anticorps Ccr4, anticorps C-C CKR-4, anticorps CHEMR1, anticorps Cmkbr4, anticorps LESTR, anticorps Sdf1r, anticorps C-C motif chemokine receptor 4, anticorps chemokine (C-C motif) receptor 4, anticorps CCR4, anticorps Ccr4

Sujet: CD194, also known as CCR4, is a CC chemokine receptor. It binds CCL17 and CCL22 and is expressed on a subset of T and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8, and these receptors are regulated differently during Th2 development. Human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. Freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs, and CCR4- Tregs require CD3-mediated activation to acquire a regulatory activity. Depletion of CCR4+ T cells leads to Th1-type polarization of CD4+ T cells and augmentation of CD8+ T cell responses to tumor antigens. CCR4 and its ligands are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.