CD276 anticorps

N° du produit ABIN2664486

Cet anticorps Souris Monoclonal détecte spécifiquement CD276 dans IHC, IP, CyTOF et ELISA (Capture). Il présente une réactivité envers Humain.

Aperçu rapide pour CD276 anticorps (ABIN2664486)

Antigène: CD276

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD276 est non-conjugé

Application: Immunohistochemistry (IHC), Immunoprecipitation (IP), Cytometry by Time of Flight (CyTOF), ELISA (Capture)

Clone: MIH42

Détail du produit anti-CD276 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CD276

Antigène: CD276

Autre désignation: CD276

Sujet: B7-H3, assigned as CD276, is a type I transmembrane protein and shares 20-27 % amino acid identity with other B7 family members. Human B7-H3 has a single extracellular variable-type immunoglobulin (IgV)-IgC domain, a signature intracellular domain, and an additional isoform, known as 4Ig-B7-H3, containing nearly exact tandem duplication of the IgV-IgC domain and most likely caused by exon duplication. B7-H3 mRNA is broadly expressed in normal tissues whereas its protein expression is relatively rare. The expression of B7-H3 is induced on T cells, natural killer (NK) cells, and antigen-presenting cells (APCs), including dendritic cells (DCs) and macrophages. It can be upregulated during the maturation from monocytes to DCs, or during the interaction between DCs and regulatory T cells. B7-H3 has been shown to be a co-stimulatory molecule that inhibits T-cell responses. B7-H3 has also been identified to bind TLT-2 involved in the intracellular signaling pathway.

Pathways: Cancer Immune Checkpoints