Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

CD301b/MGL2 anticorps

MGL2 Reactivité: Souris ELISA (Detection), ELISPOT (Detection) Hôte: Rat Monoclonal URA-1 unconjugated
N° du produit ABIN2664539
  • Antigène Tous les produits CD301b/MGL2 (MGL2)
    CD301b/MGL2 (MGL2) (Macrophage Galactose N-Acetyl-Galactosamine Specific Lectin 2 (MGL2))
    Reactivité
    Souris
    Hôte
    • 4
    • 1
    Rat
    Clonalité
    • 4
    • 1
    Monoclonal
    Conjugué
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD301b/MGL2 est non-conjugé
    Application
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA (Detection), ELISpot (Detection) (ELISPOT (Detection))
    Purification
    The antibody was purified by affinity chromatography.
    Clone
    URA-1
    Isotype
    IgG2a lambda
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Antigène
    CD301b/MGL2 (MGL2) (Macrophage Galactose N-Acetyl-Galactosamine Specific Lectin 2 (MGL2))
    Autre désignation
    CD301b (MGL2 Produits)
    Synonymes
    anticorps CD301b, anticorps macrophage galactose N-acetyl-galactosamine specific lectin 2, anticorps Mgl2
    Sujet
    Mouse CD301, also known as macrophage galactose-type C-type lectin, has two homologue genes, CD301a (MGL1) and CD301b (MGL2), while there is only one MGL in human and rat. Mouse CD301a and CD301b are ~42 kD type II transmembrane glycoproteins containing a cytoplasmic domain, a transmembrane domain, a neck domain, and a carbohydrate recognition domain (CRD) within each molecule. CD301a is mainly expressed on a subset of macrophages and immature dendritic cells (DCs). CD301b is mainly found on conventional DCs. Although CD301a and CD301b share high amino acid sequence homology (92 % for the intact sequence and 80 % for the CRD), they display different carbohydrate specificities. CD301a was found to be highly specific for Lewis X and Lewis A structures, whereas CD301b, more similar to human MGL, recognizes N-actetylgalactosamine (GalNAc) and galactose, including the O-linked Tn-antigen, TF-antigen, and core 2. So far, CD301a has been reported to be involved in recognition and endocytosis of glycoproteins with terminal Gal/GalNAc moieties. This contributes to defense against tumor cell metastasis, tissue remodeling, and clearance of apoptotic cells in embryos. CD301b is involved in the internalization of soluble polyacrylamide polymers (PAA) with α-GalNAc residues (GalNAc-PAA) in bone marrow derived DCs.
Vous êtes ici:
Support technique