DDX17 anticorps

N° du produit ABIN2664924

Cet anticorps Souris Monoclonal détecte spécifiquement DDX17 dans FACS. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour DDX17 anticorps (ABIN2664924)

Antigène: DDX17 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 17 (DDX17))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DDX17 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 1B5B09

Détail du produit anti-DDX17 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur DDX17

Antigène: DDX17 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 17 (DDX17))

Autre désignation: DDX17

Sujet: DDX17 is an ATP-dependent RNA helicase, belonging to the DEAD (Asp-Glu-Ala-Asp) box superfamily and highly related to the other key family member DDX5. The RNA helicase activity of DDX17 has been implicated in the regulation of RNA metabolism, such as RNA splicing, RNA editing, RNA degradation, and modulating secondary RNA structure. DDX17 can act as a transcriptional co-activator for the estrogen receptor ERα. It is also involved in muscle cell differentiation by co-activating MyoD. DDX17 regulates histone modification through interacting with the acetyltransferases p300, CBP, and PCAF, and the histone deacetylase HDAC1. DDX17 deficient mice exhibit severe developmental problems and die shortly after birth.

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Muscle Cell Differentiation