IL17 Receptor B anticorps

N° du produit ABIN2665122

Cet anticorps Rat Monoclonal détecte spécifiquement IL17 Receptor B dans IHC, FACS et CyTOF. Il présente une réactivité envers Souris.

Aperçu rapide pour IL17 Receptor B anticorps (ABIN2665122)

Antigène: IL17 Receptor B (IL17RB) (Interleukin 17 Receptor B (IL17RB))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp IL17 Receptor B est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)

Clone: 9B10

Détail du produit anti-IL17 Receptor B anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur IL17 Receptor B

Antigène: IL17 Receptor B (IL17RB) (Interleukin 17 Receptor B (IL17RB))

Autre désignation: IL-17RB

Sujet: IL-17RB, also known as IL17RH1, belongs to the cytokine receptor family. IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R. It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells. It binds IL-17B and IL-17E (IL-25) but not IL-17A or C. Its interaction with IL-25 has a higher affinity than that with IL-17B. Binding of IL-17RB and IL-25/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1. IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.