IRF2 anticorps

N° du produit ABIN2665203

Cet anticorps Souris Monoclonal détecte spécifiquement IRF2 dans WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour IRF2 anticorps (ABIN2665203)

Antigène: IRF2 (Interferon Regulatory Factor 2 (IRF2))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IRF2 est non-conjugé

Application: Western Blotting (WB)

Clone: 13B2A38

Détail du produit anti-IRF2 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur IRF2

Antigène: IRF2 (Interferon Regulatory Factor 2 (IRF2))

Autre désignation: IRF2

Sujet: IRF2 is a member of the IRF family of transcription factors, mainly functioning as a transcriptional repressor. It binds to the interferon-sensitive response elements (ISREs) and competes for binding sites with the other IRF transcription factors, such as IRF1 and IRF9. Mice deficient in IRF2 spontaneously develop skin inflammation due to excessive activation of CD8+ T lymphocytes. Further, the severely reduced number of mature NK cells in IRF2-deficient mice suggests that IRF2 is required for normal NK cell development. IRF2 contains a latent activation domain that can act as a transcriptional activator and has been revealed to positively regulate Histone H4 and VCAM-1 gene expression.