IRF2 anticorps
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- Antigène Voir toutes IRF2 Anticorps
- IRF2 (Interferon Regulatory Factor 2 (IRF2))
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp IRF2 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- 13B2A38
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product IRF2 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Antigène
- IRF2 (Interferon Regulatory Factor 2 (IRF2))
- Autre désignation
- IRF2 (IRF2 Produits)
- Synonymes
- anticorps IRF-2, anticorps 9830146E22Rik, anticorps AI646973, anticorps Irf-2, anticorps irf2b, anticorps zgc:103451, anticorps irf-2, anticorps wu:fc74h04, anticorps zgc:76951, anticorps interferon regulatory factor 2, anticorps interferon regulatory factor 2 L homeolog, anticorps interferon regulatory factor 2a, anticorps IRF2, anticorps Irf2, anticorps irf2, anticorps irf2.L, anticorps irf2a
- Sujet
- IRF2 is a member of the IRF family of transcription factors, mainly functioning as a transcriptional repressor. It binds to the interferon-sensitive response elements (ISREs) and competes for binding sites with the other IRF transcription factors, such as IRF1 and IRF9. Mice deficient in IRF2 spontaneously develop skin inflammation due to excessive activation of CD8+ T lymphocytes. Further, the severely reduced number of mature NK cells in IRF2-deficient mice suggests that IRF2 is required for normal NK cell development. IRF2 contains a latent activation domain that can act as a transcriptional activator and has been revealed to positively regulate Histone H4 and VCAM-1 gene expression.
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