mMCP-8 anticorps

N° du produit ABIN2665274

Cet anticorps anti- est un anticorps Rat Monoclonal détectant dans FACS et IF. Adapté pour Souris.

Aperçu rapide pour mMCP-8 anticorps (ABIN2665274)

Antigène: mMCP-8

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: TUG8

Détail du produit

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détail du antigène

Antigène: mMCP-8

Sujet: MMCP-8 and its rat homologues, rMCP-8, -9, and -10, form a new group of mast cell/basophil proteases, which are more closely related to the T-cell granzymes and neutrophil cathepsin G than to the mast cell tryptases and chymases. mMCP-8 showed a high degree of homology with mouse granzyme B in the critical regions for determining substrate cleavage specificity. It preferentially cleaves after Asp residues. mMCP-8 mRNA is highly expressed in a mouse connective tissue MC-like tumor line. However, it could not be detected in mouse liver, intestine, lung or ears, indicating very low expression in normal tissues. A strong increase in mMCP-8 levels in the lungs can be detected in infected animals.