T-Bet anticorps

N° du produit ABIN2665381

Détail du produit anti-T-Bet anticorps

Antigène: T-Bet

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp T-Bet est non-conjugé

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 4B10

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur T-Bet

Antigène: T-Bet

Abstract: T-Bet Produits

Synonymes: anticorps T-PET, anticorps T-bet, anticorps TBET, anticorps TBLYM, anticorps TBT1, anticorps Tbet, anticorps Tblym, anticorps T-box 21, anticorps TBX21, anticorps Tbx21

Sujet: T-bet, also known as T-box transcription factor T-bet, is considered to be a "master regulator" of Th1 lymphoid development controlling the production of the cytokine IFN-γ. T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. T-bet is critical for the control of microbial pathogens, and knockout animals show multiple physiologic and inflammatory features characteristic of asthma. T-bet expression is optimally observed after IL-12 stimulation and can be suppressed by addition of the Th2 cytokine IL-4 or neutralization of IL-12.