IL-33 anticorps (AA 112-270)

N° du produit ABIN2665497

Cet anticorps Chèvre Polyclonal détecte spécifiquement IL-33 dans IHC et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour IL-33 anticorps (AA 112-270) (ABIN2665497)

Antigène: IL-33 (IL33) (Interleukin 33 (IL33))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-33 est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: Poly5163

Détail du produit anti-IL-33 anticorps

Épitope: AA 112-270

Réactivité croisée (Details): In sandwich ELISA, no cross-reactivity with mouse or rat IL-33.

Purification: The antibody was purified by antigen affinity chromatography.

Immunogène: AA 112-270 (Accession# NM_033439) was expressed in E. coli.

Isotype: Ig Fraction, IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur IL-33

Antigène: IL-33 (IL33) (Interleukin 33 (IL33))

Autre désignation: IL-33

Sujet: IL-33, also known as NFHEV and DVS 27, is a 30 kD proinflammatory protein that belongs to IL-1 superfamily. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1α or IL-1β stimulation. IL-33 interacts with IL1RL1/ST2 receptor and IL-1 receptor accessory protein (IL1RAP) in order to activate intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. Recombinant IL-33 has been shown to enhance Th2-associated immune responses and potently increase mast cell proliferation and cytokine production.

Pathways: Production of Molecular Mediator of Immune Response