IL-33 anticorps (Ser109)

N° du produit ABIN2665498

L’anticorps Chèvre Polyclonal anti-IL-33 a été validé pour WB, IHC, IP et IF. Il convient pour détecter IL-33 dans des échantillons de Souris et Rat.

Aperçu rapide pour IL-33 anticorps (Ser109) (ABIN2665498)

Antigène: IL-33 (IL33) (Interleukin 33 (IL33))

Reactivité: Souris, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-33 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: Poly5165

Détail du produit anti-IL-33 anticorps

Épitope: Ser109

Réactivité croisée: Rat (Rattus)

Purification: The antibody was purified by antigen affinity chromatography.

Immunogène: Ser109-Isoleucin266 (Accession# NM_133775) was expressed in E. coli.

Isotype: Ig Fraction, IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur IL-33

Antigène: IL-33 (IL33) (Interleukin 33 (IL33))

Autre désignation: IL-33

Sujet: IL-33 belongs to the IL-1 family and is closely related in structure to IL-18 and IL-1b. IL-33, IL-1b, and IL-18 are synthesized as biologically inactive precursor and are cleaved by the enzyme caspase-1 to be secreted as active mature forms. IL-33 stimulates target cells by binding to the IL-1R/TLR superfamily member ST2 and subsequently activates NF-κB and MAPK pathways via identical signalling events to those observed for IL-1b. In addition, IL-33 is a nuclear factor (NF-HEV) abundantly expressed in high endothelial venules from lymphoid organs that associates with chromatin and exhibits transcriptional regulatory properties.

Pathways: Production of Molecular Mediator of Immune Response