IRF1 anticorps
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- Antigène Voir toutes IRF1 Anticorps
- IRF1 (Interferon Regulatory Factor 1 (IRF1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp IRF1 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- Affinity purified.
- Clone
- 13H3A44
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product IRF1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Upon receipt, store undiluted at 4°C.
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- Antigène
- IRF1 (Interferon Regulatory Factor 1 (IRF1))
- Autre désignation
- IRF1 (IRF1 Produits)
- Synonymes
- anticorps irf1, anticorps zgc:136945, anticorps IRF1, anticorps irf11, anticorps zgc:103566, anticorps IRF-1, anticorps MAR, anticorps AU020929, anticorps Irf-1, anticorps interferon regulatory factor 1, anticorps interferon regulatory factor 1a, anticorps interferon regulatory factor 1b, anticorps IRF1, anticorps irf1a, anticorps irf1b, anticorps Irf1
- Sujet
- IRF1 is the first identified member of the interferon regulatory transcription factor family. Its expression is induced in response to pathogen infection or the stimulation of several cytokines, including type I and II IFN, IL-1, IL-6, and TNF-α. Upon stimulation, IRF1 is transcriptionally activated by STAT1 and NFκB transcription factors via the GAS (interferon-gamma-activated sequence) element in the IRF1 promoter. IRF1 plays important roles in mediating immune response during infection and development of T cells and NK cells. In addition to the immunomodulatory functions, IRF1 has also shown to be involved in the regulation of cell cycle progression, tumor suppression, and apoptosis. IRF1-mediated transcription can be repressed by IRF2 through competing for the same binding region on the promoters.
- Pathways
- Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Immune Effector Process, Hepatitis C, Autophagy
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