Ataxin 3 anticorps
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- Antigène Voir toutes Ataxin 3 (ATXN3) Anticorps
- Ataxin 3 (ATXN3)
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Ataxin 3 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- 1H9-2
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product ATXN3 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.05 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Upon receipt, store undiluted between 2°C and 8°C.
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- Antigène
- Ataxin 3 (ATXN3)
- Autre désignation
- Ataxin-3 (ATXN3 Produits)
- Synonymes
- anticorps Mjd, anticorps zgc:56323, anticorps ATXN3, anticorps at3, anticorps jos, anticorps mjd, anticorps atx3, anticorps mjd1, anticorps sca3, anticorps ataxin-3, anticorps MJD1, anticorps MGC83584, anticorps AT3, anticorps ATX3, anticorps JOS, anticorps MJD, anticorps SCA3, anticorps 2210008M02Rik, anticorps AI463012, anticorps AI647473, anticorps Sca3, anticorps Rsca3, anticorps ataxin 3, anticorps ataxin 3 L homeolog, anticorps ataxin-3, anticorps atxn3, anticorps ATXN3, anticorps atxn3.L, anticorps MICPUN_104046, anticorps MICPUCDRAFT_46658, anticorps Atxn3
- Sujet
- Ataxin-3 is an ubiquitously expressed protein which contains a poly-glutamine tract. Genetically abnormal expansion of the poly-glutamine repeats results in accumulation of ubiquitinated ataxin-3 protein aggregates and leads to a neurodegenerative disorder, Machado-Joseph disease (MJD). The protein has ubiquitin interacting motifs and a N-terminal Cysteine residue (C14) responsible for its deubiquitinating activity. Ataxin-3 binds and hydrolyzes polyubiquitinated proteins, and interacts with key proteasome components, such as p97/VCP and p45, indicating that Ataxin-3 may play functional roles in ubiquitin-proteasome system. The protein also act as a transcriptional repressor when interacting with transcriptional activators and coactivators.
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