Histone H2B anticorps (H2BS14ph)

N° du produit ABIN2668331

Cité dans 1 publication. Cet anticorps anti-Histone H2B Monoclonal Souris (Clone MABI 0251) (ABIN2668331) détecte spécifiquement Histone H2B dans WB, IF et ICC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Histone H2B anticorps (H2BS14ph) (ABIN2668331)

Antigène: Histone H2B

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Histone H2B est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: MABI 0251

Détail du produit anti-Histone H2B anticorps

Épitope: H2BS14ph

Fonction: Histone H2BS14ph antibody (mAb) (Clone MABI 0251)

Purification: Protein G Chromatography

Immunogène: This Histone H2B phospho Ser14 antibody was raised against a peptide containing phospho Ser14 of human histone H2B.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.46 μg/μL

Buffer: PBS pH 7.5 containing 30 % glycerol, 0.3M NaCl and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Références pour anticorps anti-Histone H2B (ABIN2668331)

Kimura, Takizawa, Allemand, Hori, Iborra, Nozaki, Muraki, Hagiwara, Krainer, Fukagawa, Okawa: "A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B." dans: The Journal of cell biology, Vol. 175, Issue 3, pp. 389-400, (2006) (PubMed).

Détails sur Histone H2B

Antigène: Histone H2B

Sujet: Histone H2B is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points. Histone H1 is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins. H2B is phosphorylated at serine 14 in response to DNA damage (dependant upon PI3 kinase kinase activity) and during apoptosis.by the Mst1 kinase.

Poids moléculaire: 15 kDa

ID gène: 8348

NCBI Accession: NP_778225