SUV39H1 anticorps (AA 1-126)

N° du produit ABIN2668694

Cité dans 3 publications. Cet anticorps anti-SUV39H1 Monoclonal Souris (Clone MG44) (ABIN2668694) détecte spécifiquement SUV39H1 dans WB, IP, ChIP, IF et ICC. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour SUV39H1 anticorps (AA 1-126) (ABIN2668694)

Antigène: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SUV39H1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: MG44

Détail du produit anti-SUV39H1 anticorps

Épitope: AA 1-126

Fonction: SUV39H1 antibody (mAb) (Clone MG44)

Purification: Protein G Chromatography

Immunogène: This SUV39H1 antibody was raised against a recombinant protein corresponding to amino acids 1-126 of mouse SUV39H1.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Références pour anticorps anti-SUV39H1 (ABIN2668694)

Lee, Hung, Hung, Shieh: "Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer." dans: Molecular cancer, Vol. 9, pp. 64, (2010) (PubMed).

Zhou, Wang, Chen, Carmichael: "On the mechanism of induction of heterochromatin by the RNA-binding protein vigilin." dans: RNA (New York, N.Y.), Vol. 14, Issue 9, pp. 1773-81, (2008) (PubMed).

Terada: "Aurora-B/AIM-1 regulates the dynamic behavior of HP1alpha at the G2-M transition." dans: Molecular biology of the cell, Vol. 17, Issue 7, pp. 3232-41, (2006) (PubMed).

Détails sur SUV39H1

Antigène: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Autre désignation: SUV39H1

Sujet: SUV39H1 is one of two homologues of the Drosophila Suppressor-of-variegation 3(9) protein (aka Su(var)3-9). SUV39H1 is a SET domain-containing histone methyltransferase specific for lysine 9 of histone H3. Lysine 9 methylation of histone H3 is found at regions of the genome that are transcriptionally silenced, such as centromeres, repetitive elements and inactive genes. H3 lysine 9 methylation is a hallmark of heterochromatin, regions of the genome that are in a tightly compacted state and relatively devoid of gene expression. HP1 proteins recognize and bind lysine 9 methylation and this contributes to maintaining heterochromatin in its compact and inactive state. SUV39H1 also contains a chromodomain, which may bind to lysine 9 methylation and contribute to the regional spreading of lysine 9 methylation and the establishment of heterochromatin over broader domains of the genome.

Poids moléculaire: 50 kDa

ID gène: 6839

NCBI Accession: NP_035644