Retinoic Acid Receptor gamma anticorps (AA 428-441)

N° du produit ABIN2668712

Cité dans 2 publications. Cet anticorps anti-Retinoic Acid Receptor gamma Monoclonal Souris (Clone 4gamma-7A11) (ABIN2668712) détecte spécifiquement Retinoic Acid Receptor gamma dans WB, IHC et SSA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Retinoic Acid Receptor gamma anticorps (AA 428-441) (ABIN2668712)

Antigène: Retinoic Acid Receptor gamma (RARG) (Retinoic Acid Receptor, gamma (RARG))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoic Acid Receptor gamma est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Supershift Assay (SSA)

Clone: 4gamma-7A11

Détail du produit anti-Retinoic Acid Receptor gamma anticorps

Épitope: AA 428-441

Fonction: RAR-gamma antibody (mAb) (Clone 4g-7A11)

Purification: Protein G Chromatography

Immunogène: This RAR-g antibody was raised against a recombinant protein corresponding to amino acids 428-441 (F-region) of human RARg.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Références pour anticorps anti-Retinoic Acid Receptor gamma (ABIN2668712)

Hoftijzer, Liu, Morreau, van Wezel, Pereira, Corssmit, Romijn, Smit: "Retinoic acid receptor and retinoid X receptor subtype expression for the differential diagnosis of thyroid neoplasms." dans: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 160, Issue 4, pp. 631-8, (2009) (PubMed).

Reichrath, Mittmann, Kamradt, Müller: "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation." dans: The Histochemical journal, Vol. 29, Issue 2, pp. 127-33, (1997) (PubMed).

Détails sur Retinoic Acid Receptor gamma

Antigène: Retinoic Acid Receptor gamma (RARG) (Retinoic Acid Receptor, gamma (RARG))

Autre désignation: RAR-gamma

Sujet: Retinoic acid receptors (RAR) are nuclear receptors that are activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-a, RAR-b and RAR-g. RAR-g has two splice isoforms. RAR-g heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements complexed with co-repressor protein. Binding of agonist ligands to RAR results in dissociation of co-repressor and recruitment of coactivator protein which in turn promotes transcription of the downstream target gene into mRNA and eventually protein.

Poids moléculaire: 52 kDa

ID gène: 5916

NCBI Accession: NP_000957

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Cell Size