MECP2 anticorps (pSer80)

N° du produit ABIN2668830

Cet anticorps Lapin Polyclonal détecte spécifiquement MECP2 dans WB. Il présente une réactivité avec des échantillons de Humain et Rat.

Aperçu rapide pour MECP2 anticorps (pSer80) (ABIN2668830)

Antigène: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MECP2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MECP2 anticorps

Épitope: pSer80

Fonction: MeCP2 phospho Ser80 antibody (pAb)

Purification: Unpurified

Immunogène: This MeCP2 phospho Ser80 antibody was raised against a peptide containing phospho Ser80 of mouse MeCP2.

Information d'application

Indications d'application: WB: 1:2,000 - 1:10,000 dilution

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit serum containing 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur MECP2

Antigène: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Autre désignation: MeCP2

Sujet: Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as development and control of gene expression. It is generally associated with the repressive chromatin state. The complex series of events leading to this repressive state involve the coordinated regulation of DNA methyltransferases and two other groups of proteins called the Methyl-CpG binding proteins (MBD proteins) and the Kaiso family of proteins. The MBD family of proteins include MeCP2, MBD1, MBD2, MBD3 and MBD4. MeCP2 (methyl-CpG binding protein 2)can repress transcription by recruiting the Sin3 complex including histone deacetylases (HDACs). MeCP2 is distributed throughout the nucleus in human cells. Phosphorylation of MeCP2 at serine 80 may regulate the activity of neurons switching between resting and active states in neural circuits.

Poids moléculaire: 70 kDa

ID gène: 4204

NCBI Accession: NP_001075448

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane