Histone H4 anticorps (H4H18ph)

N° du produit ABIN2668870

Il existe 1 publication pour ce produit. L’anticorps anti-Histone H4 Polyclonal Lapin est utilisé pour la détection de Histone H4 dans des échantillons de Humain. Il a été validé pour WB et DB.

Aperçu rapide pour Histone H4 anticorps (H4H18ph) (ABIN2668870)

Antigène: Histone H4 (HISTH4)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Histone H4 est non-conjugé

Application: Western Blotting (WB), Dot Blot (DB)

Détail du produit anti-Histone H4 anticorps

Épitope: H4H18ph

Fonction: Histone H4H18ph antibody (pAb)

Purification: Protein A Chromatography

Immunogène: This antibody was raised against a synthetic peptide containing a 3-phosphohistidine analog at Histidine 18 of human Histone H4.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: PBS containing 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Références pour anticorps anti-Histone H4 (ABIN2668870)

Kee, Villani, Carpenter, Muir: "Development of stable phosphohistidine analogues." dans: Journal of the American Chemical Society, Vol. 132, Issue 41, pp. 14327-9, (2010) (PubMed).

Détails sur Histone H4

Antigène: Histone H4 (HISTH4)

Autre désignation: Histone H4

Sujet: Histone H4 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points, it is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation, they play a major role in regulating gene expression. Phosphorylation of histidines in Histone H4 has been known to occur in liver cells and may be associated with proliferation of hepatocytes during regeneration of the liver following damage.

Poids moléculaire: 8 kDa

ID gène: 121504

NCBI Accession: NP_778224