TNFSF8 anticorps

N° du produit ABIN2688991

Détail du produit anti-TNFSF8 anticorps

Antigène: TNFSF8 (Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNFSF8 est non-conjugé

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: Reacts with CD30 ligand (CD153) a 40 kDa type II membrane glycoprotein expressed mainly on activated T cells, as well as on activated macrophages, neutrophils and both normal and malignant B cells. CD30 ligand is a member of the tumor necrosis factor (TNF) superfamily. In addition to TNF, this family also includes lymphotoxin α (LTα), LTβ, CD154, CD95L, CD70, CD134 ligand, CDw137 ligand, and TRAIL. Results of in vitro studies have shown that CD30 mediates a variety of activation and differentiation, or apoptotic signals. Recently, it has been reported that CD30-deficient mice have elevated numbers of thymocytes and show a gross defect in negative but not positive selection during T cell differentiation, suggesting an important role for CD30/CD30L interactions in the deletion of autoreactive T cells. Profile of PMA & CA++ ionophore- stimulated peripheral blood lymphocytes analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD153 - Purified - Clone D2-1173 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: D2

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-TNFSF8 (ABIN2688991)

Romagnani, Annunziato, Manetti, Mavilia, Lasagni, Manuelli, Vannelli, Vanini, Maggi, Pupilli, Romagnani: "High CD30 ligand expression by epithelial cells and Hassal's corpuscles in the medulla of human thymus." dans: Blood, Vol. 91, Issue 9, pp. 3323-32, (1998) (PubMed).

Del Prete, De Carli, DElios, Daniel, Almerigogna, Alderson, Smith, Thomas, Romagnani: "CD30-mediated signaling promotes the development of human T helper type 2-like T cells." dans: The Journal of experimental medicine, Vol. 182, Issue 6, pp. 1655-61, (1996) (PubMed).

Smith, Gruss, Davis, Anderson, Farrah, Baker, Sutherland, Brannan, Copeland, Jenkins: "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF." dans: Cell, Vol. 73, Issue 7, pp. 1349-60, (1993) (PubMed).

Détails sur TNFSF8

Antigène: TNFSF8 (Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8))

Autre désignation: CD153 (TNFSF8 Produits)

Synonymes: anticorps CD153, anticorps CD30LG, anticorps Cd30l, anticorps CD30L, anticorps TNFRSF8, anticorps TNFSF8, anticorps tumor necrosis factor (ligand) superfamily, member 8, anticorps TNF superfamily member 8, anticorps tumor necrosis factor superfamily member 8, anticorps Tnfsf8, anticorps TNFSF8

Sujet: Synonyms: CD30L