CCR6 anticorps

N° du produit ABIN2689057

Détail du produit anti-CCR6 anticorps

Antigène: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCR6 est non-conjugé

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: The monoclonal antibody 11A9 reacts with the human CC chemokine receptor, CCR6. CCR6 (previously known as BN-1, CKR-L3, DRY6, GPR-CY4 and STRL22), a seven-transmembrane, G-protein-coupled receptor, is the specific receptor for CC chemokine MIP-3a/LARC/ Exodus. It has been shown that CCR6 mRNA is expressed mainly in lymphoid tissues including spleen, lymph nodes, thymus, appendix. CCR6 mRNA was also detected in peripheral T- and B-lymphocytes and in CD34-derived dendritic cells. The human CCR6 gene, unlike other CCR genes, has been mapped to chromosome 6q27. The immunogen used to generate 11A9 hybridoma was KLH-conjugated N-terminus peptides of human CCR6. It does not cross-react with human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CCR8, CCR9, CXCR1, CXCR2, CXCR3, CXCR4 and CXCR5 transfectants. This antibody is NOT a neutralizing antibody. CCR6 had been clustered as CD196 in the VIIIth HLDA workshop. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Expression of human CCR6 on peripheral lymphocytes detected by purified 11A9.

BD Pharmingen™ Purified Mouse Anti-Human CD196 (CCR6) - Purified - Clone 11A9 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: 11A9

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-CCR6 (ABIN2689057)

Liao, Alderson, Su, Ullrich, Kreider, Farber: "STRL22 is a receptor for the CC chemokine MIP-3alpha." dans: Biochemical and biophysical research communications, Vol. 236, Issue 1, pp. 212-7, (1997) (PubMed).

Power, Church, Meyer, Alouani, Proudfoot, Clark-Lewis, Sozzani, Mantovani, Wells: "Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells." dans: The Journal of experimental medicine, Vol. 186, Issue 6, pp. 825-35, (1997) (PubMed).

Baba, Imai, Nishimura, Kakizaki, Takagi, Hieshima, Nomiyama, Yoshie: "Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC." dans: The Journal of biological chemistry, Vol. 272, Issue 23, pp. 14893-8, (1997) (PubMed).

Greaves, Wang, Dairaghi, Dieu, Saint-Vis, Franz-Bacon, Rossi, Caux, McClanahan, Gordon, Zlotnik, Schall: "CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells." dans: The Journal of experimental medicine, Vol. 186, Issue 6, pp. 837-44, (1997) (PubMed).

Liao, Lee, Farber: "Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27." dans: Genomics, Vol. 40, Issue 1, pp. 175-80, (1997) (PubMed).

Zaballos, Varona, Gutiérrez, Lind, Márquez: "Molecular cloning and RNA expression of two new human chemokine receptor-like genes." dans: Biochemical and biophysical research communications, Vol. 227, Issue 3, pp. 846-53, (1996) (PubMed).

Détails sur CCR6

Antigène: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Autre désignation: CD196 CCR6 (CCR6 Produits)

Synonymes: anticorps BN-1, anticorps C-C CKR-6, anticorps CC-CKR-6, anticorps CCR-6, anticorps CD196, anticorps CKR-L3, anticorps CKRL3, anticorps CMKBR6, anticorps DCR2, anticorps DRY6, anticorps GPR29, anticorps GPRCY4, anticorps STRL22, anticorps Cmkbr6, anticorps KY411, anticorps C-C motif chemokine receptor 6, anticorps chemokine (C-C motif) receptor 6, anticorps CCR6, anticorps Ccr6

Sujet: Synonyms: CCR6

Pathways: cAMP Metabolic Process