CD1d anticorps

N° du produit ABIN2689067

Cet anticorps Rat Monoclonal détecte spécifiquement CD1d dans FACS, IP, IF, IHC (fro) et BR. Il présente une réactivité envers Souris et a été mentionné dans 6+ publications.

Aperçu rapide pour CD1d anticorps (ABIN2689067)

Antigène: CD1d (CD1D) (CD1d Molecule (CD1D))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD1d est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)

Clone: 3C11

Détail du produit anti-CD1d anticorps

Marque: BD Pharmingen™

Attributs du produit: The 3C11 antibody reacts with CD1d, a 48- kDa glycoprotein with structural homology to the major histocompatibility complex (MHC) class I molecules. The structure, expression, and functions of CD1 antigens are complex and have been reviewed. mAb 3C11 detects CD1d at varying levels on most types of bone marrow and peripheral leukocytes and on epithelial, dendritic, and lymphoid cells in the thymus. It appears to recognize CD1d only in association with β2m. CD1d has been reported to be expressed by gastrointestinal tract epithelium and in the cytoplasm of hepatocytes as detected via immunohistochemical staining of frozen sections with mAb 3C11, suggesting a possible role for CD1d in mucosal immunity. However, CD1d expression was not detectable, via flow cytometry, on intestinal epithelial cells in studies using the anti-CD1d mAbs 3C11, 1B1 (Cat. no. 553843, for the purified antibody), and 9C7. The 3C11 mAb is reported to cross-react with human CD1d, and it competes with mAb 1B1 (Cat. no. 553844) in binding to mouse splenocytes.

BD Pharmingen™ Purified Rat Anti-Mouse CD1d - Purified - Clone 3C11 - Isotype Rat IgM, κ - Reactivity Ms - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: L cells (derived from C3H/An mouse) expressing full-length mouse Cd1.1 cDNA

Isotype: IgM kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-CD1d (ABIN2689067)

Porcelli, Modlin: "The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids." dans: Annual review of immunology, Vol. 17, pp. 297-329, (1999) (PubMed).

Amano, Baumgarth, Dick, Brossay, Kronenberg, Herzenberg, Strober: "CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 4, pp. 1710-7, (1998) (PubMed).

Roark, Park, Jayawardena, Kavita, Shannon, Bendelac: "CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3121-7, (1998) (PubMed).

Sydora, Brossay, Hagenbaugh, Kronenberg, Cheroutre: "TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 11, pp. 4209-16, (1996) (PubMed).

Balk, Burke, Polischuk, Frantz, Yang, Porcelli, Colgan, Blumberg: "Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium." dans: Science (New York, N.Y.), Vol. 265, Issue 5169, pp. 259-62, (1994) (PubMed).

Bleicher, Balk, Hagen, Blumberg, Flotte, Terhorst: "Expression of murine CD1 on gastrointestinal epithelium." dans: Science (New York, N.Y.), Vol. 250, Issue 4981, pp. 679-82, (1990) (PubMed).

Détails sur CD1d

Antigène: CD1d (CD1D) (CD1d Molecule (CD1D))

Autre désignation: CD1d

Sujet: Synonyms: CD1.1, Ly-38

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process