MUC1 anticorps

N° du produit ABIN2689099

Détail du produit anti-MUC1 anticorps

Antigène: MUC1 (Mucin 1 (MUC1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MUC1 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Marque: BD Pharmingen™

Attributs du produit: Reacts with the core peptide of the MUC1 protein, a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kDa) and an amino acid composition rich in serine, threonin, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats which function as multiple epitopes for the monoclonal antibody. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This antibody has been shown to react with both normal and malignant epithelia of various tissues including breast and colon. Profile of U266 cells analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD227 - Purified - Clone HMPV - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: HMPV

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-MUC1 (ABIN2689099)

Treon, Mollick, Urashima, Teoh, Chauhan, Ogata, Raje, Hilgers, Nadler, Belch, Pilarski, Anderson: "Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone." dans: Blood, Vol. 93, Issue 4, pp. 1287-98, (1999) (PubMed).

Nakamura, Hinoda, Nakagawa, Makiguchi, Itoh, Endo, Imai: "Detection of circulating anti-MUC1 mucin core protein antibodies in patients with colorectal cancer." dans: Journal of gastroenterology, Vol. 33, Issue 3, pp. 354-61, (1998) (PubMed).

Reddish, MacLean, Koganty, Kan-Mitchell, Jones, Mitchell, Longenecker: "Anti-MUC1 class I restricted CTLs in metastatic breast cancer patients immunized with a synthetic MUC1 peptide." dans: International journal of cancer. Journal international du cancer, Vol. 76, Issue 6, pp. 817-23, (1998) (PubMed).

Agrawal, Schatz: "RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination." dans: Cell, Vol. 89, Issue 1, pp. 43-53, (1997) (PubMed).

Devine, Birrell, Whitehead, Harada, Xing, McKenzie: "Expression of MUC1 and MUC2 mucins by human tumor cell lines." dans: Tumour biology, Vol. 13, Issue 5-6, pp. 268-77, (1993) (PubMed).

Xing, Prenzoska, Layton, Devine, McKenzie: "Second-generation monoclonal antibodies to intestinal MUC2 peptide reactive with colon cancer." dans: Journal of the National Cancer Institute, Vol. 84, Issue 9, pp. 699-703, (1992) (PubMed).

Détails sur MUC1

Antigène: MUC1 (Mucin 1 (MUC1))

Autre désignation: CD227 (MUC1 Produits)

Synonymes: anticorps CA 15-3, anticorps CD227, anticorps EMA, anticorps H23AG, anticorps KL-6, anticorps MAM6, anticorps MCKD1, anticorps MUC-1, anticorps MUC-1/SEC, anticorps MUC-1/X, anticorps MUC1/ZD, anticorps PEM, anticorps PEMT, anticorps PUM, anticorps Muc-1, anticorps mucin 1, cell surface associated, anticorps mucin 1, transmembrane, anticorps MUC1, anticorps Muc1

Sujet: Synonyms: MUC1

Pathways: Negative Regulation of intrinsic apoptotic Signaling