F11R anticorps

N° du produit ABIN2689190

Détail du produit anti-F11R anticorps

Antigène: F11R (F11 Receptor (F11R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp F11R est non-conjugé

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: The M.Ab.F11 monoclonal antibody specifically binds to CD321 which is also known as JAM-1 (Junctional adhesion molecule 1), Junctional adhesion molecule A (JAM-A), and F11 Receptor (F11R). CD321 is a 32-35 kDa type I transmembrane glycoprotein that includes two extracellular immunoglobulin-like domains. CD321 is expressed on platelets, leucocytes, red blood cells, endothelial cells, epithelial cells, and various cell lines. CD321 functions as an adhesion receptor molecule on platelets. It also supports the tight junction formation between endothelial cells, where it may regulate the transendothelial migration of leucocytes, and epithelial cells. M.Ab.F11 is a stimulatory antibody that can induce morphological changes, granule secretion, and aggregation in human platelets. Flow cytometric analysis of human CD321 staining on platelets. Peripheral blood platelets were stained with either Purified Mouse Anti-Human CD321 (JAM-1) (Cat. No. 552147, solid line histogram) or Purified Mouse IgG1, κ Isotype Control (Cat. No. 555746, dashed line histogram), followed by second step staining with FITC Goat Anti-Mouse IgG/IgM (Cat. No. 555988).

BD Pharmingen™ Purified Mouse Anti-Human CD321 (JAM-1) - Purified - Clone M.Ab.F11 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: M-Ab-F11

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-F11R (ABIN2689190)

Florian, Sonneck, Czerny, Hennersdorf, Hauswirth, Bühring, Valent: "Detection of novel leukocyte differentiation antigens on basophils and mast cells by HLDA8 antibodies." dans: Allergy, Vol. 61, Issue 9, pp. 1054-62, (2006) (PubMed).

Horváth, Drbel, Angelisová, Hilgert, Horejsí: "Non-lineage antigens: section report." dans: Cellular immunology, Vol. 236, Issue 1-2, pp. 42-7, (2005) (PubMed).

Babinska, Kedees, Athar, Sobocki, Sobocka, Ahmed, Ehrlich, Hussain, Kornecki: "Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion." dans: Thrombosis and haemostasis, Vol. 87, Issue 4, pp. 712-21, (2002) (PubMed).

Sobocka, Sobocki, Banerjee, Weiss, Rushbrook, Norin, Hartwig, Salifu, Markell, Babinska, Ehrlich, Kornecki: "Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation." dans: Blood, Vol. 95, Issue 8, pp. 2600-9, (2000) (PubMed).

Kornecki, Walkowiak, Naik, Ehrlich: "Activation of human platelets by a stimulatory monoclonal antibody." dans: The Journal of biological chemistry, Vol. 265, Issue 17, pp. 10042-8, (1990) (PubMed).

Détails sur F11R

Antigène: F11R (F11 Receptor (F11R))

Autre désignation: CD321 JAM-1 (F11R Produits)

Synonymes: anticorps CD321, anticorps JAM, anticorps JAM1, anticorps JAMA, anticorps JCAM, anticorps KAT, anticorps PAM-1, anticorps 9130004G24, anticorps AA638916, anticorps ESTM33, anticorps JAM-1, anticorps JAM-A, anticorps Jcam, anticorps Jcam1, anticorps Ly106, anticorps Jam1, anticorps F11 receptor, anticorps F11R, anticorps F11r

Sujet: Synonyms: JAM-1, Platelet F11 receptor, F11R, JAM-A, PAM-1

Pathways: Cell-Cell Junction Organization