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NCR1 anticorps

NCR1 Reactivité: Humain FACS Hôte: Souris Monoclonal 9E2-NKp46 unconjugated
N° du produit ABIN2689196
  • Antigène Voir toutes NCR1 Anticorps
    NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))
    Reactivité
    • 73
    • 54
    • 20
    • 9
    • 4
    • 4
    Humain
    Hôte
    • 55
    • 26
    • 15
    Souris
    Clonalité
    • 58
    • 38
    Monoclonal
    Conjugué
    • 36
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Cet anticorp NCR1 est non-conjugé
    Application
    • 51
    • 29
    • 23
    • 13
    • 13
    • 10
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Marque
    BD Pharmingen™
    Attributs du produit
    The 9E2/Nkp46 monoclonal antibody specifically binds to CD335. CD335 is also known as the Natural killer cell p46-related protein (NKp46) and the Natural cytotoxicity triggering receptor 1 (NCR1). CD335 is a 46 kDa type I membrane glycoprotein that is expressed on resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3ζ. Its intracellular region does not contain immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with CD3ζ and FcεRIγ adaptor proteins. CD335 along with NKp30 and NKp44 are referred to as natural cytotoxicity receptors (NCR). These receptors play very important roles in cells that kill virus-infected target cells, tumor cells and MHC-class I-unprotected cells. Profile of CD335 (NKp46) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

    BD Pharmingen™ Purified Mouse Anti-Human CD335 (NKp46) - Purified - Clone 9E2/NKp46 (also known as 9-E2) - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Clone
    9E2-NKp46
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product NCR1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Mandelboim, Porgador: "NKp46." dans: The international journal of biochemistry & cell biology, Vol. 33, Issue 12, pp. 1147-50, (2001) (PubMed).

    Nakajima, Cella, Bouchon, Grierson, Lewis, Duckett, Cohen, Colonna: "Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity." dans: European journal of immunology, Vol. 30, Issue 11, pp. 3309-18, (2001) (PubMed).

    Sivori, Pende, Bottino, Marcenaro, Pessino, Biassoni, Moretta, Moretta et al.: "NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against ..." dans: European journal of immunology, Vol. 29, Issue 5, pp. 1656-66, (1999) (PubMed).

    Sivori, Vitale, Morelli, Sanseverino, Augugliaro, Bottino, Moretta, Moretta: "p46, a novel natural killer cell-specific surface molecule that mediates cell activation." dans: The Journal of experimental medicine, Vol. 186, Issue 7, pp. 1129-36, (1997) (PubMed).

  • Antigène
    NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))
    Autre désignation
    CD335 NKp46 (NCR1 Produits)
    Synonymes
    anticorps CD335, anticorps LY94, anticorps NK-p46, anticorps NKP46, anticorps Ly94, anticorps NKp46, anticorps KILR-1, anticorps Nk-p46, anticorps Nkp46, anticorps natural cytotoxicity triggering receptor 1, anticorps NCR1, anticorps Ncr1
    Pathways
    Regulation of Leukocyte Mediated Immunity
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