ITGA5 anticorps

N° du produit ABIN2689316

Cet anticorps Rat Monoclonal détecte spécifiquement ITGA5 dans FACS, IHC (fro), IF, IHC (p) et BR. Il présente une réactivité envers Souris et a été mentionné dans 10+ publications.

Aperçu rapide pour ITGA5 anticorps (ABIN2689316)

Antigène: ITGA5 (Integrin, alpha 5 (ITGA5))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGA5 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Blocking Reagent (BR)

Clone: 5H10

Détail du produit anti-ITGA5 anticorps

Marque: BD Pharmingen™

Attributs du produit: The 5H10-27 (MFR5) antibody reacts with the α5 chain of the integrin α5β1 fibronectin receptor (CD49e/CD29, VLA-5) on thymocytes, activated T lymphocytes, mast cells, and a variety of mouse cell lines, but not splenocytes. Soluble 5H10-27 (MFR5) antibody has been reported to inhibit VLA-5-mediated functions in vitro. In addition, immobilized mAb 5H10-27 (MFR5) has been demonstrated to costimulate the proliferative response of CD8+ T cells to plate-bound anti-CD3e antibody. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

BD Pharmingen™ Purified Rat Anti-Mouse CD49e - Purified - Clone 5H10-27 (MFR5) - Isotype Rat IgG2a, κ - Reactivity Ms - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse mast cell line MC/9

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-ITGA5 (ABIN2689316)

Makwana, Werner, Acosta-Saltos, Gonitel, Pararajasingam, Pararajasingham, Ruff, Rumajogee, Cuthill, Galiano, Bohatschek, Wallace, Anderson, Mayer, Behrens, Raivich: "Peripheral facial nerve axotomy in mice causes sprouting of motor axons into perineuronal central white matter: time course and molecular characterization." dans: The Journal of comparative neurology, Vol. 518, Issue 5, pp. 699-721, (2010) (PubMed).

Cukierman, Pankov, Stevens, Yamada: "Taking cell-matrix adhesions to the third dimension." dans: Science (New York, N.Y.), Vol. 294, Issue 5547, pp. 1708-12, (2001) (PubMed).

Yang, Hynes: "Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins." dans: Molecular biology of the cell, Vol. 7, Issue 11, pp. 1737-48, (1997) (PubMed).

Rich, Van Nood, Lee: "Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8+ T cell growth and apoptosis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 7, pp. 2916-23, (1996) (PubMed).

Ruppert, Aigner, Hubbe, Yagita, Altevogt: "The L1 adhesion molecule is a cellular ligand for VLA-5." dans: The Journal of cell biology, Vol. 131, Issue 6 Pt 2, pp. 1881-91, (1996) (PubMed).

Uhlenkott, Huijzer, Cardeiro, Elstad, Meadows: "Attachment, invasion, chemotaxis, and proteinase expression of B16-BL6 melanoma cells exhibiting a low metastatic phenotype after exposure to dietary restriction of tyrosine and phenylalanine." dans: Clinical & experimental metastasis, Vol. 14, Issue 2, pp. 125-37, (1996) (PubMed).

Gomez, Cano: "Expression of beta 1 integrin receptors in transformed mouse epidermal keratinocytes: upregulation of alpha 5 beta 1 in spindle carcinoma cells." dans: Molecular carcinogenesis, Vol. 12, Issue 3, pp. 153-65, (1995) (PubMed).

Halvorson, Coligan: "Enhancement of VLA integrin receptor function on thymocytes by cAMP is dependent on the maturation stage of the thymocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 10, pp. 4567-74, (1995) (PubMed).

Hardy, Minguell: "Modulation of the adhesion of hemopoietic progenitor cells to the RGD site of fibronectin by interleukin 3." dans: Journal of cellular physiology, Vol. 164, Issue 2, pp. 315-23, (1995) (PubMed).

Kinashi, Springer: "Adhesion molecules in hematopoietic cells." dans: Blood cells, Vol. 20, Issue 1, pp. 25-44, (1995) (PubMed).

Détails sur ITGA5

Antigène: ITGA5 (Integrin, alpha 5 (ITGA5))

Autre désignation: CD49e

Sujet: Synonyms: Integrin α5 chain

Pathways: Integrin Complex