Gp49 Receptor anticorps

N° du produit ABIN2689526

Cet anticorps Hamster arménien Monoclonal détecte spécifiquement Gp49 Receptor dans FACS, IP et ELISA. Il présente une réactivité avec des échantillons de Souris. Il a été cité dans 4+ publications.

Aperçu rapide pour Gp49 Receptor anticorps (ABIN2689526)

Antigène: Gp49 Receptor

Reactivité: Souris

Hôte: Hamster arménien

Clonalité: Monoclonal

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA

Clone: H1-1

Détail du produit

Attributs du produit: The H1.1 antibody reacts with gp49B, a structural homolog of the human Killer Inhibitory Receptors (KIR), and with the truncated related molecule gp49A. The gp49 receptors are expressed on myeloid cells of adult bone marrow, spleen, and liver and fetal liver. They are not found on resting lymphoid cells, but their expression is upregulated on activated NK cells. gp49B is a member of the Ig superfamily containing two cytoplasmic ITIM (Immunoreceptor Tyrosine-based Inhibitory Motif) domains, while gp49A has no ITIM. Although its ligand is unknown, it is established that cross-linking of gp49B can suppress cell activation events.

BD Pharmingen™ Purified Hamster Anti-Mouse gp49 Receptor - Purified - Clone H1.1 - Isotype Armenian Hamster IgG3, κ - Reactivity Ms - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: gp49B-Fc fusion protein composed of extracelluar domain of gp49B

Isotype: IgG3 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Référence

McCormick, Castells, Austen, Katz et al.: "The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory receptors of the immunoglobulin ..." dans: Immunogenetics, Vol. 50, Issue 5-6, pp. 286-94, (2000) (PubMed).

Wang, Chu, Dokun, Yokoyama: "Inducible expression of the gp49B inhibitory receptor on NK cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 10, pp. 5215-20, (2000) (PubMed).

Wang, Blasioli, Plas, Thomas, Yokoyama: "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1318-23, (1999) (PubMed).

Wang, Mehta, LeBlanc, Yokoyama: "Mouse natural killer cells express gp49B1, a structural homologue of human killer inhibitory receptors." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 1, pp. 13-7, (1997) (PubMed).

Détail du antigène

Antigène: Gp49 Receptor