Aminoacylase 1 anticorps

N° du produit ABIN2716050

Cet anticorps Souris Monoclonal détecte spécifiquement Aminoacylase 1 dans WB, IHC et FACS. Il présente une réactivité envers Humain, Souris, Rat et Chien.

Aperçu rapide pour Aminoacylase 1 anticorps (ABIN2716050)

Antigène: Aminoacylase 1 (ACY1)

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Aminoacylase 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 1A12

Détail du produit anti-Aminoacylase 1 anticorps

Attributs du produit: Homo sapiens aminoacylase 1 (ACY1), transcript variant 1

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogène: Full length human recombinant protein of human ACY1(NP_000657) produced in HEK293 cell.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:500~2000, IHC 1:150, FLOW 1:100,

Commentaires:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur Aminoacylase 1

Antigène: Aminoacylase 1 (ACY1)

Autre désignation: ACY1

Sujet: This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

Poids moléculaire: 45.7 kDa

ID gène: 95

NCBI Accession: NM_000666

HGNC: 95