TGFB3 anticorps

N° du produit ABIN271851

Détail du produit anti-TGFB3 anticorps

Antigène: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TGFB3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of pro-TGF-beta-3 (47 kDa) and cleaved-TGF-beta-3 (13 kDa) protein. (region surrounding Gly292)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur TGFB3

Antigène: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Autre désignation: TGF-beta-3 (TGFB3) (TGFB3 Produits)

Synonymes: anticorps TGFB3, anticorps ARVD, anticorps TGF-beta3, anticorps Tgfb-3, anticorps TGF-B3, anticorps TGFbeta3, anticorps wu:fc78g09, anticorps zgc:92058, anticorps transforming growth factor beta 3, anticorps transforming growth factor, beta 3, anticorps TGFB3, anticorps Tgfb3, anticorps tgfb3

Sujet: Transforming Growth Factor beta 3 (TGF beta 3) is a member of the TGF beta family of growth factors. The TGF beta polypeptides are multifunctional, capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors, and essentially all mammalian cells possess a specific TGF receptor. The multi-modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide. A high level of TGF beta 3 in normal adult heart, lung, and brain suggests a possible role for this factor in the regulation of a variety of normal physiological functions. The expression of TGF beta 3 in different locations and at specific stages of embryogenesis suggests its involvement in the regulation of development. Similar to the other isoforms of TGF beta, the upregulated activation of TGF beta 3 might also be involved in a variety of pathological conditions. TGF beta 3 has been detected in human, porcine, and avian sources and is expressed in cells of mesenchymal origin, suggesting a different role for this protein than for TGF beta 1 or TGF beta 2. TGF beta 3 is less prevalent in natural expression than either TGF beta 1 or TGF beta 2, but is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord and in several human carcinoma cells.Synonyms: Transforming growth factor beta-3

Poids moléculaire: 13 and 47 kDa

ID gène: 7043

NCBI Accession: NP_003230

UniProt: P10600

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus