THRB anticorps
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- Antigène Voir toutes THRB Anticorps
- THRB (Thyroid Hormone Receptor, beta (THRB))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp THRB est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects endogenous levels of Thyroid Hormone Receptor beta protein. (region surrounding Leu37)
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- Affinity Chromatography using epitope-specific immunogen
- Top Product
- Discover our top product THRB Anticorps primaire
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- Indications d'application
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ELISA: 1/5000-1/10000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- THRB (Thyroid Hormone Receptor, beta (THRB))
- Autre désignation
- THRB / ERBA2 (THRB Produits)
- Synonymes
- anticorps C-ERBA-2, anticorps C-ERBA-BETA, anticorps ERBA2, anticorps GRTH, anticorps NR1A2, anticorps PRTH, anticorps THR1, anticorps THRB1, anticorps THRB2, anticorps Nr1a2, anticorps T3R[b], anticorps T3Rbeta, anticorps Thrb1, anticorps Thrb2, anticorps c-erbAbeta, anticorps TR-beta, anticorps TR[b]1, anticorps fj24f03, anticorps trb, anticorps wu:fj24f03, anticorps CTR BETA 2, anticorps TR-BETA, anticorps LOC734147, anticorps thrb, anticorps THRB, anticorps C-erba-beta, anticorps RATT3REC, anticorps T3rec, anticorps TRbeta, anticorps THR, anticorps TRbeta1, anticorps thyroid hormone receptor beta, anticorps thyroid hormone receptor, beta, anticorps thyroid hormone receptor, beta S homeolog, anticorps thyroid hormone receptor, beta L homeolog, anticorps THRB, anticorps Thrb, anticorps thrb, anticorps thrb.S, anticorps thrb.L
- Sujet
- Thyroid hormone nuclear receptors (TRs) are ligand-dependent transcription factors which regulate growth, differentiation and development and represent members of the steroid/retinoic acid superfamily. The two genes encoding TRs identified to date, TRα and TRβ, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements(TREs) with half-site binding motifs in the orientation of palindromes, direct repeats or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3'-triiodo-L-thyronine (T3). Transcriptional regulation by TRs is also modulated by heterodimerization with TR nuclear accessory proteins, the most extensively characterized of which are the retinoid X receptors (RXRα, RXRβ and RXRγ). To a certain extent, this activity is regulated by differential phosphorylation of TRs. Thus, not only are the biological activities of TRs regulated by heterodimerization with RXRs, but in addition, the gene regulatory activities of TRs are linked to other hormonal pathways.Synonyms: NR1A2, Nuclear receptor subfamily 1 group A member 2, THR1, Thyroid hormone receptor beta
- Poids moléculaire
- approx. 42, 55 kDa
- ID gène
- 7068
- NCBI Accession
- NP_000452
- UniProt
- P10828
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound
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