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NCF4 anticorps

NCF4 Reactivité: Humain, Souris IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN272048
  • Antigène Voir toutes NCF4 Anticorps
    NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
    Reactivité
    • 81
    • 25
    • 11
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Humain, Souris
    Hôte
    • 76
    • 5
    • 1
    Lapin
    Clonalité
    • 78
    • 4
    Polyclonal
    Conjugué
    • 37
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp NCF4 est non-conjugé
    Application
    • 41
    • 26
    • 26
    • 20
    • 16
    • 12
    • 7
    • 4
    • 4
    • 3
    • 3
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody detects endogenous levels of p40 phox protein. (region surrounding Arg149)
    Réactivité croisée (Details)
    Species reactivity (tested):Human, Mouse.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Pureté
    > 95 % pure by SDS-PAGE
    Top Product
    Discover our top product NCF4 Anticorps primaire
  • Indications d'application
    ELISA: 1: 10000approx. 1: 20000. IHC: 1: 50approx. 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    DO NOT FREEZE!
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
    Autre désignation
    NCF-4 (NCF4 Produits)
    Synonymes
    anticorps p40phox, anticorps AI451400, anticorps NCF, anticorps P40PHOX, anticorps SH3PXD4, anticorps neutrophil cytosolic factor 4, anticorps ncf4, anticorps Ncf4, anticorps NCF4
    Sujet
    Nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase is a multimeric enzyme system that mediates electron transport from NADPH in the cytoplasm to molecular oxygen in the phagosome, thereby generating reactive oxidant intermediates. Upon neutrophil stimulation, NADPH-oxidase and other cytosolic elements localize to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. There are a number of cytosolic proteins that are involved in NADPH-oxidase activation/deactivation,including p47-phox, p67-phox, p40-phox and the small GTP-binding protein, Rac. Activation of NADPH oxidase is accompanied by the phosphorylation of cytosolic components p40-phox, p47-phox and p67-phox. The PKC consensus phosphorylation sites Thr 154 and Ser 315 in p40-phox are phosphorylated during activation of NADPH oxidase. p40-phox can promote oxidase activation by increasing the affinity of p47-phox for NADPH-oxidase. However, p40-phox appears to downregulate oxidase function as well, by competing with an SH3 domain interaction between other essential oxidase components.Synonyms: Neutrophil NADPH oxidase factor 4, Neutrophil cytosol factor 4, SH3 and PX domain-containing protein 4, SH3PXD4, p40-phox
    Poids moléculaire
    approx. 39 kDa
    ID gène
    4689
    NCBI Accession
    NP_000622
    UniProt
    Q15080
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