PAR1 anticorps

N° du produit ABIN272129

Détail du produit anti-PAR1 anticorps

Antigène: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAR1 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of PAR1 protein. (region surrounding Gly17)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/10000approx. 1/20000. Western blot: 1/500approx. 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in alqiuots) at -20 °C for longer.

Détails sur PAR1

Antigène: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Autre désignation: Thrombin Receptor / F2R (F2R Produits)

Synonymes: anticorps CF2R, anticorps HTR, anticorps PAR-1, anticorps PAR1, anticorps TR, anticorps Par1, anticorps TRGPC, anticorps AI482343, anticorps Cf2r, anticorps ThrR, anticorps Par-1, anticorps f2r-a, anticorps par1, anticorps coagulation factor II thrombin receptor, anticorps coagulation factor II (thrombin) receptor, anticorps coagulation factor 2 (thrombin) receptor L homeolog, anticorps F2R, anticorps F2r, anticorps f2r.L

Sujet: Thrombin receptor (also designated protease-activated receptor-1 or PAR-1), PAR-2 and PAR-3 compose a distinct class of G protein-coupled receptors activated by proteolysis. Cleavage of these receptors by proteases occurs within the amino-terminal extracellular domain. Thrombin, a serine protease involved in platelet aggregation and blood coagulation, activates the thrombin receptor, resulting in elevated intracellular calcium levels in platelets. Thrombin also cleaves PAR-3 in vitro, suggesting that PAR-3 may be involved in thrombosis or mitogenesis. Thrombin receptor and PAR-4 appear to account for most thrombin signaling in platelets. Activation of PAR-2 in vitro is induced by trypsin, suggesting that PAR-2 is not an alternative thrombin receptor. Cytokines including TNF-alpha and IL-1beta increase PAR-2 expression, indicating PAR-2 involvement in the acute inflammatory response.Synonyms: CF2R, Coagulation factor II receptor, PAR-1, PAR1, Proteinase-activated receptor 1

Poids moléculaire: approx. 48 kDa

ID gène: 2149

NCBI Accession: NP_001983

UniProt: P25116

Pathways: Nuclear Receptor Transcription Pathway, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus