HNRNPL anticorps

N° du produit ABIN272168

L’anticorps anti-HNRNPL Polyclonal Lapin est utilisé pour la détection de HNRNPL dans des échantillons de Humain et Souris. Il a été validé pour WB, IF et IHC (p).

Aperçu rapide pour HNRNPL anticorps (ABIN272168)

Antigène: HNRNPL (Heterogeneous Nuclear Ribonucleoprotein L (HNRNPL))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNRNPL est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-HNRNPL anticorps

Specificité: This antibody detects endogenous levels of hnRNP L protein. (region surrounding Gly58)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur HNRNPL

Antigène: HNRNPL (Heterogeneous Nuclear Ribonucleoprotein L (HNRNPL))

Autre désignation: HnRNP-L / HNRNPL

Sujet: Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription, pre-mRNA processing and mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II). There are approximately 20 known hnRNP proteins, which range in size from 34 kDa to 120 kDa, and their complexes are the majorconstituents of the spliceosome. The majority of hnRNP proteins components are localized to the nucleus, however some shuttle between the nucleus and the cytoplasm. hnRNP I, also designated polypyrimidine tract-binding protein (PTB) and its homolog hnRNP L bind to the 3' end of introns to modulate alternative splicing mechanisms of pre-mRNAs in normal cells and the translation of several viruses, including hepatitis C virus (HCV). The human hnRNP I gene maps to chromosome 19p13.3 and encodes a 57 kDa protein that is localized in the nucleoplasm. hnRNP L has a molecular mass of 68 kDa and like hnRNP I, is also localized in the nucleoplasm.Synonyms: HNRPL, Heterogeneous nuclear ribonucleoprotein L, P/OKcl.14

Poids moléculaire: approx. 60 kDa

ID gène: 3191

NCBI Accession: NP_001005335

UniProt: P14866