EGR2 anticorps
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- Antigène Voir toutes EGR2 Anticorps
- EGR2 (Early Growth Response 2 (EGR2))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp EGR2 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects endogenous levels of Egr-2 protein. (region surrounding Arg409)
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- Pureté
- > 95 % pure by SDS-PAGE
- Top Product
- Discover our top product EGR2 Anticorps primaire
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- Indications d'application
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- DO NOT FREEZE!
- Stock
- 4 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C.
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- Antigène
- EGR2 (Early Growth Response 2 (EGR2))
- Autre désignation
- EGR2 (EGR2 Produits)
- Synonymes
- anticorps AT591, anticorps CMT1D, anticorps CMT4E, anticorps KROX20, anticorps Egr-2, anticorps Krox-20, anticorps Krox20, anticorps NGF1-B, anticorps Zfp-25, anticorps Zfp-6, anticorps KRX-20, anticorps cb427, anticorps egr2, anticorps id:ibd5073, anticorps krox20, anticorps krx20, anticorps wu:fb71h10, anticorps zgc:92210, anticorps frb35, anticorps early growth response 2, anticorps early growth response 2b, anticorps early growth response 2a, anticorps EGR2, anticorps Egr2, anticorps egr2b, anticorps egr2a
- Sujet
- Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation and function. The deduced amino acid sequences of human Egr-2 and mouse Egr-1 are 92 % identical in the zinc finger region but show no homology elsewhere. Egr-2 is a sequence-specific DNA-binding transcription factor that binds two specific DNA sites located in the promoter region of HoxA4 and localizes to the nucleus. Defects in the Egr-2 protein are a cause of congenital hypomyelination neuropathy (CHN). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness and very slow nerve conduction velocities. Mutations in the gene that encodes Egr-2 (EGR2) also cause of Dejerine-Sottas syndrome (DSS), which is also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS patients exhibit severe early onset motor and sensory neuropathy with very slow nerve conduction velocities and elevated cerebrospinal fluid protein concentrations.Synonyms: AT591, EGR-2, Early growth response protein 2, KROX20, Krox 20, Zinc finger protein Krox-20
- Poids moléculaire
- approx. 50 kDa
- ID gène
- 1959
- NCBI Accession
- NP_000390
- UniProt
- P11161
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