CDK5R2 anticorps

N° du produit ABIN272221

Cet anticorps Lapin Polyclonal détecte spécifiquement CDK5R2 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour CDK5R2 anticorps (ABIN272221)

Antigène: CDK5R2 (Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (p39) (CDK5R2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK5R2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CDK5R2 anticorps

Specificité: This antibody detects endogenous levels of p39 protein. (region surrounding asn100)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur CDK5R2

Antigène: CDK5R2 (Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (p39) (CDK5R2))

Autre désignation: CDK5R2

Sujet: Cyclin dependent kinases, known as Cdks, regulate transitions in the eukaryotic cell cycle. Cdk 5 is required for proper development of the mammalian central nervous system and is predominantly expressed in neurons. Neuronal Cdk5 can be activated by two accessory proteins designated p35nck5a and p39nck5ai, which is also known as p39. The human p39 gene maps to chromosome 2q35 and encodes a 367-amino acid, 39 kDa protein. p35 and p39 both share limited similarity to cyclins and may define a distinct family of cyclin-dependent kinase activating proteins. During embryonic rat brain development, the expression pattern of p39 appears to have an inverse relationship to that of Cdk5 and p35, suggesting that these proteins may have region-specific and developmental stage-specific functions in rat brain. p39 can localize to lamellipodial and fillopodial structures of cells and in growth cones of neurons. In addition, p39 can colocalize with actin, suggesting that p39 plays a role in regulating actin cytoskeletal dynamics in cells. The temporal and spatial expression of p39 in synaptic junctions indicates a possible role of the p39/cdk5 kinase at the synapse.Synonyms: CDK5 activator 2, Cyclin-dependent kinase 5 activator 2, Cyclin-dependent kinase 5 regulatory subunit 2, NCK5AI, P39, P39I

Poids moléculaire: approx. 40 kDa

ID gène: 8941

NCBI Accession: NP_003927

UniProt: Q13319