PDE4B anticorps

N° du produit ABIN2728510

Il existe 1 publication pour ce produit. L’anticorps anti-PDE4B Monoclonal Souris est utilisé pour la détection de PDE4B dans des échantillons de Humain et Souris. Il a été validé pour WB, IHC, FACS et IF.

Aperçu rapide pour PDE4B anticorps (ABIN2728510)

Antigène: PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PDE4B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 1D12

Détail du produit anti-PDE4B anticorps

Attributs du produit: Homo sapiens phosphodiesterase 4B, cAMP-specific (PDE4B), transcript variant a

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogène: Full length human recombinant protein of human PDE4B(NP_002591) produced in HEK293T cell.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100,

Commentaires:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-PDE4B (ABIN2728510)

Johanns, Lai, Hsu, Jacobs, Vertommen, Van Sande, Dumont, Woods, Carling, Hue, Viollet, Foretz, Rider: "AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B." dans: Nature communications, Vol. 7, pp. 10856, (2016) (PubMed).

Détails sur PDE4B

Antigène: PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))

Autre désignation: PDE4B

Sujet: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Poids moléculaire: 83.2 kDa

ID gène: 5142

NCBI Accession: NM_002600

HGNC: 5142

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction