GPX8 anticorps (AA 38-209)

N° du produit ABIN2745532

Détail du produit anti-GPX8 anticorps

Antigène: GPX8 (Glutathione Peroxidase 8 (GPX8))

Épitope: AA 38-209

Reactivité: Hepatitis C Virus (HCV)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPX8 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Specificité: Recognizes human GPx8.

Réactivité croisée: Hepatitis C Virus (HCV)

Immunogène: Recombinant GPx8 (human) (aa 38-209) fused to a GST-tag.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur GPX8

Antigène: GPX8 (Glutathione Peroxidase 8 (GPX8))

Autre désignation: GPx8 (GPX8 Produits)

Synonymes: anticorps RGD1307506, anticorps zgc:56280, anticorps EPLA847, anticorps GPx-8, anticorps GSHPx-8, anticorps UNQ847, anticorps 2310016C16Rik, anticorps AU017063, anticorps ATGPX8, anticorps F2K11.16, anticorps F2K11_16, anticorps glutathione peroxidase 8, anticorps glutathione peroxidase 8, anticorps glutathione peroxidase 8 (putative), anticorps Gpx8, anticorps gpx8, anticorps GPX8

Classe de substances: Viral Protein

Sujet: GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione (GSH) as reductant. GPx8 (probable glutathione peroxidase 8) is a 209-aa, 24 kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum (ER) lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.

UniProt: Q8TED1

Pathways: Thyroid Hormone Synthesis