GPX8 anticorps (AA 38-209)

N° du produit ABIN2745532

Cet anticorps anti-GPX8 Polyclonal Lapin (ABIN2745532) détecte spécifiquement GPX8 dans WB et ICC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour GPX8 anticorps (AA 38-209) (ABIN2745532)

Antigène: GPX8 (Glutathione Peroxidase 8 (GPX8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPX8 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Détail du produit anti-GPX8 anticorps

Épitope: AA 38-209

Fonction: anti-GPx8 (human), pAb (IN103)

Specificité: Recognizes human GPx8.

Attributs du produit: Polyclonal Antibody. Recognizes human GPx8. Source: Rabbit. Applications: ICC, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione (GSH) as reductant. GPx8 (probable glutathione peroxidase 8) is a 209-aa, 24 kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum (ER) lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.

Immunogène: Recombinant GPx8 (human) (aa 38-209) fused to a GST-tag.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur GPX8

Antigène: GPX8 (Glutathione Peroxidase 8 (GPX8))

Autre désignation: GPx8

Sujet:

Alternate Names/Synonyms: Probable Glutathione Peroxidase 8, GSHPx-8

Product Description: GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione (GSH) as reductant. GPx8 (probable glutathione peroxidase 8) is a 209-aa, 24 kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum (ER) lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.

UniProt: Q8TED1

Pathways: Thyroid Hormone Synthesis