AZGP1 anticorps

N° du produit ABIN2745583

Détail du produit anti-AZGP1 anticorps

Antigène: AZGP1 (alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp AZGP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: Recognizes human zinc-alpha-2-glycoprotein.

Réactivité croisée: Humain

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant human zinc-alpha-2-glycoprotein.

Clone: Zagy-1

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur AZGP1

Antigène: AZGP1 (alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1))

Autre désignation: ZAG (AZGP1 Produits)

Synonymes: anticorps Zag, anticorps ZA2G, anticorps ZAG, anticorps ZA2GA, anticorps Zna2gp, anticorps alpha-2-glycoprotein 1, zinc, anticorps alpha-2-glycoprotein 1, zinc-binding, anticorps Azgp1, anticorps AZGP1

Sujet: Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vivo experiments. Due to its expression in and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices.

UniProt: P25311

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process