The mouse monoclonal antibody CARL-1 recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types.
Reactivité: Humain
FACS, IHC, Func
Hôte: Souris
Monoclonal
CARL-1
PE
Indications d'application
Flow cytometry: Recommended dilution: 1-4 μg/mL.
Restrictions
For Research Use only
Concentration
1 mg/mL
Buffer
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store at 2-8°C. Do not freeze.
Yoriki, Akashi, Sho, Nomi, Yamato, Hotta, Takayama, Matsumoto, Wakatsuki, Migita, Yagita, Nakajima: "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer." dans: Experimental and therapeutic medicine, Vol. 2, Issue 1, pp. 103-108, (2012) (PubMed).
Brown, Ghosh, Winkles: "Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway." dans: The Journal of biological chemistry, Vol. 285, Issue 23, pp. 17432-41, (2010) (PubMed).
Hosokawa, Hosokawa, Ozaki, Nakae, Matsuo: "Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts." dans: Clinical and experimental immunology, Vol. 146, Issue 3, pp. 540-9, (2006) (PubMed).
Saitoh, Nakayama, Nakano, Yagita, Yamamoto, Yamaoka: "TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation." dans: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36005-12, (2003) (PubMed).
Nakayama, Kayagaki, Yamaguchi, Okumura, Yagita: "Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity." dans: The Journal of experimental medicine, Vol. 192, Issue 9, pp. 1373-80, (2000) (PubMed).
Antigène
CD255
Autre désignation
CD255 / TWEAK
Sujet
TNF superfamily member 12,CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.,TNFSF12, APO3L, DR3LG, TWEAK, TNLG4A