PCLO anticorps

N° du produit ABIN2749094

Cet anticorps Souris Monoclonal détecte spécifiquement PCLO dans WB et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour PCLO anticorps (ABIN2749094)

Antigène: PCLO (Piccolo (Presynaptic Cytomatrix Protein) (PCLO))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PCLO est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: PCLO-01

Détail du produit anti-PCLO anticorps

Fonction: Anti-PCLO Purified

Specificité: The mouse monoclonal antibody PCLO-01 recognizes PCLO (Piccolo), a more than 400 kDa multidomain protein expressed mainly in the presynaptic cytoplasmatic matrix of the neurons.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Human recombinant PCLO protein

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-5 μg/mL, intracellular staining.
Western blotting: A small splice variant of PCLO can be analyzed by Western blotting, however, the whole protein is too large (over 400 kDa) to be successfully processed by SDS PAAGE.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détails sur PCLO

Antigène: PCLO (Piccolo (Presynaptic Cytomatrix Protein) (PCLO))

Autre désignation: PCLO

Sujet: Piccolo presynaptic cytomatrix protein,PCLO (piccolo, also known as aczonin) is a large (more than 400 kDa) multidomain protein of the presynaptic cytomatrix in neurons, that is present in all vertebrate synapses, but is absent from invertebrates. It contains zinc finger and coiled-coil sequences, as well as N-terminal glutamine-rich sequence, and C-terminal PDZ domain followed by two C2 domains (C2A and C2B). In vitro binding and transfection experiments suggested that PCLO binds to multiple proteins including profilin and L-type calcium channels. It is involved in neurotransmitter release and insulin secretion.,ACZ, PCH3, piccolo, aczonin

ID gène: 27445

UniProt: Q9Y6V0

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis