CD79b anticorps (APC)

N° du produit ABIN2749136

Cet anticorps Souris Monoclonal détecte spécifiquement CD79b dans FACS. Il présente une réactivité envers Humain et a été mentionné dans 6+ publications.

Aperçu rapide pour CD79b anticorps (APC) (ABIN2749136)

Antigène: CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD79b est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Clone: CB3-1

Détail du produit anti-CD79b anticorps (APC)

Fonction: Anti-Hu CD79b APC

Specificité: The mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta, Ig beta), an approximately 38 kDa component of B cell receptor (BCR) complex.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Fraction of Ig-associated molecules isolated from Ramos B cells

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Stockage

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-CD79b (APC) (ABIN2749136)

Dornan, Bennett, Chen, Dennis, Eaton, Elkins, French, Go, Jack, Junutula, Koeppen, Lau, McBride, Rawstron, Shi, Yu, Yu, Yue, Zheng, Ebens, Polson: "Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma." dans: Blood, Vol. 114, Issue 13, pp. 2721-9, (2009) (PubMed).

Zheng, Fuji, Elkins, Yu, Fuh, Chuh, Tan, Hongo, Raab, Kozak, Williams, McDorman, Eaton, Ebens, Polson: "In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates." dans: Molecular cancer therapeutics, Vol. 8, Issue 10, pp. 2937-46, (2009) (PubMed).

Matutes: "New additions to antibody panels in the characterisation of chronic lymphoproliferative disorders." dans: Journal of clinical pathology, Vol. 55, Issue 3, pp. 180-3, (2002) (PubMed).

DArena, Cascavilla, Musto, Colella Bisogno, Pistolese, Carotenuto: "CD79b expression in B-cell chronic lymphocytic leukemia." dans: Haematologica, Vol. 85, Issue 5, pp. 556-7, (2000) (PubMed).

Rassenti, Kipps: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." dans: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).

Nakamura, Kubagawa, Cooper: "Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8522-6, (1992) (PubMed).

Détails sur CD79b

Antigène: CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))

Autre désignation: CD79b

Sujet: CD79b molecule,CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR beta, Ig-beta, B29, IGB

ID gène: 974

UniProt: P40259

Pathways: BCR Signaling