LARGE1 (AA 35-142) anticorps (PE)

N° du produit ABIN2749158

L’anticorps Souris Monoclonal anti- a été validé pour ICFC. Il convient pour détecter dans des échantillons de Humain.

Aperçu rapide pour LARGE1 (AA 35-142) anticorps (PE) (ABIN2749158)

Antigène: LARGE1

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: PE

Application: Intracellular Flow Cytometry (ICFC)

Clone: LARGE-02

Détail du produit

Épitope: AA 35-142

Fonction: Anti-LARGE1 PE

Specificité: The mouse monoclonal antibody LARGE-02 recognizes human LARGE1, a glycosyltransferase expressed mainly in the Golgi apparatus. Crossreactivity with LARGE2 was not determined.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Recombinant fragment of human LARGE1 (amino acids 35-142)

Isotype: IgG2b

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-5 μg/mL. Intracellular staining.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Détail du antigène

Antigène: LARGE1

Sujet: LARGE xylosyl- and glucuronyltransferase 1,LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.,Xysosyl- and glucosyl transferase 1

ID gène: 9215

UniProt: O95461