CD68 anticorps

N° du produit ABIN2749213

Détail du produit anti-CD68 anticorps

Antigène: CD68 (CD68 Molecule (CD68))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD68 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: The mouse monoclonal antibody Y1/82A recognizes CD68 (LAMP4), a 110 kDa glycoprotein expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Lysosomal contents of lung macrophages

Clone: Y1-82A

Isotype: IgG2b

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 2-6 μg/mL. Extracellular and intracellular staining.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD68 (ABIN2749213)

Yamagami, Yokoo, Amano, Ebihara: "Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva." dans: Investigative ophthalmology & visual science, Vol. 48, Issue 10, pp. 4476-81, (2007) (PubMed).

Mack, Tucker, Sokol, Karrer, Kotzin, Whitington, Miller: "Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation." dans: Pediatric research, Vol. 56, Issue 1, pp. 79-87, (2004) (PubMed).

Ulanova, Tarkowski, Hahn-Zoric, Hanson: "The Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism." dans: Infection and immunity, Vol. 69, Issue 2, pp. 1151-9, (2001) (PubMed).

Doussis, Gatter, Mason: "CD68 reactivity of non-macrophage derived tumours in cytological specimens." dans: Journal of clinical pathology, Vol. 46, Issue 4, pp. 334-6, (1993) (PubMed).

Holness, Simmons: "Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins." dans: Blood, Vol. 81, Issue 6, pp. 1607-13, (1993) (PubMed).

Détails sur CD68

Antigène: CD68 (CD68 Molecule (CD68))

Autre désignation: CD68 (CD68 Produits)

Synonymes: anticorps Lamp4, anticorps Scard1, anticorps gp110, anticorps GP110, anticorps LAMP4, anticorps SCARD1, anticorps CD68 molecule, anticorps CD68 antigen, anticorps Cd68 molecule, anticorps CD68, anticorps Cd68

Sujet: CD68 Molecule,CD68 (also known as LAMP4 or SCARD1) is a 110 kDa type I transmembrane glycoprotein of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family and the scavenger receptor family. Although CD68 primarily localizes to lysosomes and endosomes, its fraction circulates to the cell surface. By the heavily glycosylated extracellular domain CD68 binds to tissue- and organ-specific lectins or selectins. It is expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells, but also e.g. in a proportion of epithelial tumours (diagnosis of poorly differentiated neoplasms).,GP110, LAMP4, SCARD1

ID gène: 968

UniProt: P34810