OTC anticorps (N-Term)

N° du produit ABIN2773791

Cet anticorps anti-OTC est un anticorps Lapin Polyclonal détectant OTC dans WB et IHC. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc, Mouton, Lapin, Chévre et Cobaye. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour OTC anticorps (N-Term) (ABIN2773791)

Antigène: OTC (Ornithine Carbamoyltransferase (OTC))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc, Mouton, Lapin, Chévre, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-OTC anticorps

Épitope: N-Term

Séquence: AFRNGHNFMV RNFRCGQPLQ NKVQLKGRDL LTLKNFTGEE IKYMLWLSAD

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against OTC. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human OTC

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 354 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-OTC (ABIN2773791)

Hallows, Yu, Smith, Devries, Devires, Ellinger, Someya, Shortreed, Prolla, Markley, Smith, Zhao, Guan, Denu: "Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction." dans: Molecular cell, Vol. 41, Issue 2, pp. 139-49, (2011) (PubMed).

Walters, Wallace: "Urea cycle gene expression is suppressed by PFOA treatment in rats." dans: Toxicology letters, Vol. 197, Issue 1, pp. 46-50, (2010) (PubMed).

Yu, Lin, Yao, Huang, Lei, Xiong, Zhao, Guan: "Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals." dans: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13669-75, (2009) (PubMed).

Tanaka, Wada, Maruyama, Tanaka, Takikawa, Komatsu: "Hyperammonemia-induced encephalopathy due to ornithine transcarbamylase deficiency in an adult woman: identification of novel missense mutations." dans: Journal of gastroenterology, Vol. 40, Issue 1, pp. 106-7, (2005) (PubMed).

Détails sur OTC

Antigène: OTC (Ornithine Carbamoyltransferase (OTC))

Autre désignation: OTC

Sujet: OTC is a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.
Alias Symbols: OCTD
Protein Interaction Partner: OTC, TOMM20,
Protein Size: 354

Poids moléculaire: 39 kDa

ID gène: 5009

NCBI Accession: NM_000531, NP_000522

UniProt: P00480