MRVI1 anticorps (N-Term)

N° du produit ABIN2773963

Cet anticorps Lapin Polyclonal détecte spécifiquement MRVI1 dans WB. Il présente une réactivité envers Humain, Boeuf (Vache), Chien, Cobaye, Cheval, Souris, Lapin et Rat.

Aperçu rapide pour MRVI1 anticorps (N-Term) (ABIN2773963)

Antigène: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Reactivité: Humain, Boeuf (Vache), Chien, Cobaye, Cheval, Souris, Lapin, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MRVI1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MRVI1 anticorps

Épitope: N-Term

Séquence: LVNDQLPDIS ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MRVI1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MRVI1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MRVI1

Antigène: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Autre désignation: MRVI1

Sujet: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Protein Interaction Partner: MME, PRKG1, ITPR1,
Protein Size: 803

Poids moléculaire: 88 kDa

ID gène: 10335